Position Description

Research Associate/Sr. Research Associate, Cell Metabolism
Location Agios Pharmaceuticals HQ
Job Code 686
# of openings 1
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Research Associate/Sr. Research Associate – Cell Metabolism

Agios (agios.com) is a biopharmaceutical company committed to applying our scientific leadership in cellular metabolism to transform the lives of patients with cancer and rare genetic diseases. We are growing rapidly with an active research and discovery pipeline across both therapeutic areas. Agios has two approved oncology precision medicines and multiple first-in-class investigational therapies in clinical and/or preclinical development.

Agios Pharmaceuticals is searching for a dynamic Research Associate/Sr. Research Associate to join our growing Cell Metabolism team.  You will be responsible for the design and execution of metabolomics and targeted LCMS experiments to support drug discovery efforts in cancer metabolism, immuno-oncology, and rare genetic disorders.  You will have the ability to work cross-functionally as a contribution member to project teams. This role will be primarily lab focused supporting multiple aspects of our pre-clinical pipeline

The Cell Metabolism department focuses on quantitatively understanding cellular metabolism, relying on state-of-the-art mass spectrometry methods for proteomics, metabolomics, and isotopic labeling studies. Our work includes characterization of the metabolism of tumors with specific genetic features, including the metabolism of both cancer cells and immune cells, as well as metabolic effects of rare genetic disorders.

Key Responsibilities

  • Execute metabolomic assays to assess perturbations in cellular metabolism in a variety of disease settings, including cancer metabolism, immunology, and rare genetic diseases.
  • Improve and troubleshoot established LCMS metabolomics methods, from sample processing to data analysis.
  • Validate new LCMS methods supporting metabolomics analysis
  • Document, analyze, and suggest interpretation of experiments; present results and conclusions in a variety of team settings.
  • Maintain good written records of laboratory procedures, results and conclusions.

Minimum Requirements

  • BS or MS preferred, with 3+ years experience. BS required, with 1+ years of experience or MS with 0+ years experience.
  • Ability to work with multiple LCMS instruments and vendor types
  • Experience with liquid chromatography and mass spectrometry methods for small molecule analysis
  • Basic understanding of cellular metabolism in relation to disease progression
  • Self-motivated and able to work independently or in a small team with minimal supervision.
  • Excellent communication and organizational skills.
  • Excellent problem-solving skills and ability to multi-task.

Preferred Qualifications

  • GCMS experience a plus
  • Mammalian cell culture experience a plus
  • Variety of analytical chemistry experience applied to the analysis of biomolecules

Competencies:

  • Know & Show your Stuff: Possesses technical or professional expertise and is able to apply it at Agios to create value/impact.
  • Collaborates: Work in and with teams to achieve outcomes that individuals would not have been able to achieve alone.
  • Demonstrates critical and creative thinking to solve problems
  • Talks straight: Open and authentic in conversations; cultivates trust in interactions.
  • Executes and Operates to a High Standard in delivering results to project teams.
  • Improves Continuously: Takes an approach to continuous improvement; anticipates and addresses capability gaps to prepare for future challenges.
  • Builds networks internally to establish an effective collaborative environment
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